1. How do I prevent phone numbers looking twice as large and having a Skype highlight?

If this is occurring, it is because a user has the Skype browser extension installed. Use the following CSS to prevent Skype from formatting the numbers on your page:

span.skype_pnh_container {
    display: none !important;
}

span.skype_pnh_print_container {
    display: inline !important;
}

2. How can I integrate Twitter Bootstrap with HTML5 Boilerplate?

You can use Initializr to create a custom build that includes HTML5 Boilerplate with Twitter Bootstrap.

Read more about how HTML5 Boilerplate and Twitter Bootstrap complement each other.

3. Minify Your CSS

Here is a Free CSS Compressor and CSS Compression Tool: http://www.minifycss.com/css-compressor

4. CSS tips

Here are some CSS Best Practices extracted from the book ‘Visual QuickStart Guide’ by ‘Jason Cranford Teague’.

• Prefer shorthand properties. use ‘Font’ to set multiple values with a single property.
  This not only cuts down on the amount of code, it also keeps similar property values together, makeing editing easier.
• Use RGB for color:
  RGB values are easier for mere mortals to understan and you can now set transparent colors using RGBA.
• Use background images or other styles for interface chrome.
• Use CSS form simple background gradients.
• Favor margin over padding.
• Favor over @import.